You're here: My Science Blogging » Discovery » Article: Two Proteins Interact As Survival Marker in Breast Cancers
Yessi Pratiwi — November 24, 2007 / 9:49 pm
Recently, the researchers at the Ohio State University Comprehensive Cancer Center in collaboration with researchers in Finland suggests that the presence or absence of two proteins may be important markers for long-term survival in some breast-cancer patients.
A proteins called ErbB-4, is important for the growth and differentiation of several types of cells in the body. The second protein, called Wwox, is a tumor suppressor – it helps prevent cells from becoming cancerous – and it is missing in many breast cancers.
The interaction of these two proteins is clinically important in breast cancer, the researchers said. Their absence is associated with shorter survival in breast cancer. Furthermore, the study shows that Wwox keeps ErbB4 on the cell surface, and that this is associated with better survival. They suggest that these proteins can be used as clinical markers that predict better survival.
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