You're here: My Science Blogging » Discovery » Article: Fuels Of Heart Play Important Roles in Heart Function
Yessi Pratiwi — November 18, 2007 / 10:51 pm
Genes play a significant role in heart function, and may partly determine who develops the most common form of heart failure. More than one-fourth of adults over age 45 have abnormalities in the way their heart fills with blood and are at significantly increased risk for premature death.
Data from a 15-year period show that the prevalence of a particular type of heart failure — heart failure with preserved ejection fraction, also known as diastolic heart failure — is increasing.
Jason Dyck and his research team at the University of Alberta have been studying the types of fuels used by the heart in young and aged mice. The young healthy heart normally used a balance of fat and sugar to generate energy to allow the heart to beat and pump blood efficiently. Dyck proposed that the mismatch between fat uptake and fat use in the heart could lead to an accumulation of fat in the heart resulting in an age-related decrease in heart function.
Using a genetically engineered mouse that is deficient in a protein that is responsible for transporting fat into the cells of the heart, Dyck studied these mice as they aged. It conclude that the protein responsible for transporting fat into the contractile cells of the heart may be a candidate for drug inhibition and that this drug could protect the heart from aging.
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