You're here: My Science Blogging » Discovery » Article: Genetic Variation May Lower HIV Load
Yessi Pratiwi — July 23, 2007 / 6:28 pm
Using DNA sequences determined from patient blood samples, a research found that by a small genetic mutation in the section of human DNA that codes for immune proteins appears able to reduce the amount of HIV in the body by an average of 90%. The finding points to new ways in which vaccines might one day help boost immune protection against the virus, some scientist says.
The research tried to understand how genetic differences among these 500 people could influence how well their bodies kept HIV under control. People with this tiny sequence variation, dubbed rs9264942, appear to have up to 90% less virus in their systems than those who carry other polymorphisms. A patient whose virus levels initially settle at a lower number has a much better prognosis than someone whose infection stabilizes at a higher amount. The new results from the study suggest that a vaccine to stimulate the action of HLA-C could help fight HIV.
Before this research, the studies have found that certain genetic mutations, such the rare CCR5 mutation, can offer protection against the virus, but the new report is the first to show the impact of a variant affecting HLA-C.
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